Together, they focus on a shared goal:

Creating a world without cancer.


Research Groups:
Medicinal Chemistry

Medicinal Chemistry

This program is focused on central activities required for the development of small organic molecules as cancer chemotherapeutic agents. Members of this program use a wide variety of approaches, including chemical, biochemical, cellular, and animal methods to design and discover drugs. These approaches include (but are not limited to):

  • Natural Product-Based Drug Design and Discovery – Synthesis of anticancer natural products and analogs thereof and biological studies on their mechanism of action.
  • Biologically-Targeted Drug Design – Design, synthesis, and biological evaluation of synthetic compounds as potential inhibitors of anticancer enzyme targets, and antagonists of anticancer receptors.
  • Screening of Biological Targets for Drug Discovery – Development and utilization of methods, including systems biology methods, for the high-throughput evaluation of potential anticancer agents.
  • Preclinical Models for Drug Development – Evaluation of potential chemotherapeutic and chemopreventive agents in cellular and animal cancer models.

Specific examples of activities in this program include:

  • Development of new synthetic routes to natural products known to function as antitumor or chemopreventive agents.
  • Mechanistic evaluation of new anticancer natural products.
  • Design and synthesis of targeted protein kinase inhibitors.
  • Design and synthesis of inhibitors of post-translational modifications.
  • Design and synthesis of topoisomerase inhibitors.
  • Development of systems methods for discovery of novel potential anticancer targets.
  • Studies of potential chemotherapeutic agents in mouse xenograph and other animal models.

Program Members

View our entire membership list


  • Purdue University Center for Cancer Research
    Hansen Life Sciences Research Building
    201 S. University Street
    West Lafayette, IN 47907-2064

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