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Research

Resources: MASS SPECTROMETRY

Mass Spectometry

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Overview

Mass spectrometry is an essential analytical technique for the identification and structure elucidation of the wide variety of compounds that are important to the Purdue University Center for Cancer Research (PCCR) members’ research projects. These projects include studies on the design and synthesis of therapeutic agents for cancer treatment, the creation of diagnostic agents, and the investigation of basic cellular processes involved in cancer cell biology. Of additional importance is the ability of mass spectrometry to sort out reaction products to facilitate increased yield and understand where a reaction might be going wrong when the expected product is not obtained.

As part of the Campus-wide Mass Spectrometry Center, the Mass Spectrometry Shared Resource (MS-SR) provides PCCR members access to all of the facility’s mass spectrometers. This includes support for both routine analyses and collaborative analytical mass spectrometric capabilities (including problem solving by mass spectrometry). Taking advantage of the MS-SR staff’s experience, in addition to routine mass spectrometry analyses, considerable effort has been made to make each of the ionization techniques a center of excellence for solving the difficult mass spectrometry research problems associated with PCCR research projects. The MS-SR currently has six mass spectrometers available to PCCR members. This includes Electrospray Ionization (ESI), Matrix-Assisted Laser Desorption Ionization (MALDI) and Atmospheric Pressure Chemical Ionization (APCI) for the analysis of nonvolatile components, Electron Impact (EI) and Chemical Ionization (CI) for volatile components, and Inductively Coupled Argon Plasma Ionization (ICP) for multi-element analysis.

Equipment

Drug Discovery Building (DRUG)

  • ABI Voyager DE Pro
    (Matrix-Assisted Laser Desorption) Nonvolatile compounds to m/z 100,000
  • Agilent 5975C GC/MS
    (Electron Impact/Chemical Ionization capillary GC/MS) Volatile components to m/z 1000
  • Agilent 6550 Q-TOF
    (Electrospray Ionization and High Resolution Mass Measurement; LC/MS/MS) Nonvolatile components to m/z 50,000
  • ABI 4800
    (Matrix-Assisted Laser Desorption Ionization and MS/MS ) Nonvolatile compounds to m/z 100,000

 Wetherill Chemistry Building (WTHR)

  • FinniganMAT ELEMENT2
    (Inductively Coupled Argon Plasma) Multi-element Analysis
  • Agilent 6320 Trap LC/MS
    (Electrospray and Atmospheric Pressure Chemical Ionization; LC/MS/MS) Nonvolatile components to m/z 50,000
  • Hewlett Packard Engine
    (Electron Impact/Chemical Ionization probe and capillary GC/MS) Volatile components to m/z 1000
  • ThermoFisher LTQ Orbitrap
    (Laser Ablation Electrospray Ionization and High Resolution Mass Measurement

Services & Pricing

  Faculty in Subsidizing Department No Department Subsidy
Service PCCR
member
Non-PCCR
member
PCCR
member
Non-PCCR
member
MALDI $ 15.06 $ 31.62 $ 31.35 $ 47.91
GC/MS $ 15.06 $ 31.62 $ 31.35 $ 47.91
ICP $ 5.02 $ 10.54 $ 10.45 $ 15.97
PROBE EI/CI $ 15.06 $ 31.62 $ 31.35 $ 47.91
APCI $ 15.06 $ 31.62 $ 31.35 $ 47.91
ESPRAY LR $ 15.06 $ 31.62 $ 31.35 $ 47.91
ESPRAY HR $ 15.06 $ 31.62 $ 31.35 $ 47.91
PROBE HR $ 15.06 $ 31.62 $ 31.35 $ 47.91
LC/MS $ 15.06 $ 31.62 $ 31.35 $ 47.91

Per Sample Cost billed in 0.50 Hr Units.

Contact Information & Location

    • Shared Resources Director: Karl Wood
    • E-mail: kvw@purdue.edu
    • Phone: (765) 494 - 7357
    • Building/Room: WTHR 157
  • Locations of Mass Spectrometry SR Facilities

  • Purdue University Center for Cancer Research
    Hansen Life Sciences Research Building
    201 S. University Street
    West Lafayette, IN 47907-2064

  • Phone: (765) 494-9129
    Fax: (765) 494-9193
    Contact us with questions at:
    cancerresearch@purdue.edu

© Copyright 2014 The Purdue University Center for Cancer Research is the first NCI funded Center in Indiana.